Why the study?
Are low levels of HDL-C associated with the presence of CAD in patients with aortic aneurysms?
Are low levels of HDL-C associated with the presence of CAD in patients with aortic aneurysms?
In patients with aortic aneurysms planned for surgery, low HDL-C levels are an independent predictor of concomitant coronary artery disease.
Low HDL-C may flag higher CAD risk in aortic aneurysm patients; hypothesis-generating for preoperative screening, does not yet change practice.
To identify predictors of the presence of coronary artery disease (CAD) in patients with planned surgery for aortic aneurysms, we reviewed clinical profiles and angiography records of 191 patients with aortic aneurysms (34 thoracic, 137 abdominal, and 20 thoracoabdominal; 162 men; mean age, 75.2 ± 7.7 years). The incidence of CAD was 38.7% among all the patients. Patients with CAD had significantly low levels of high-density lipoprotein cholesterol (HDL-C) as compared with patients without CAD (45 ± 9 vs 51 ± 13 mg/dL; P = .009). Multivariate analysis showed that only low HDL-C levels were associated with the presence of CAD (adjusted odds ratio, 0.946; 95% confidence interval, 0.911-0.983; P = .004). The optimal cutoff level of HDL-C to predict CAD was 47.50 mg/dL. The CAD is common in patients with aortic aneurysms, and low levels of HDL-C are independently associated with the presence of CAD.
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Saigusa et al. (2013) studied this question.
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