Key result
Higher HDL cholesterol was associated with lower cardiovascular mortality in people without CAD (HR 0.37; 95% CI 0.18-0.74), but this relationship was not significant in patients with CAD.
Why the study?
Does the presence of coronary artery disease impact the predictive value of HDL cholesterol for cardiovascular mortality?
Cohort (n=3,141)
Yes
Does the presence of coronary artery disease impact the predictive value of HDL cholesterol for cardiovascular mortality?
Effect estimate: HR 0.37 (95% CI 0.18-0.74)
p-value: p=0.005
The inverse relationship between HDL cholesterol and cardiovascular mortality is significant in individuals without coronary artery disease but is lost in patients with established stable or unstable CAD, limiting its utility for risk stratification in this population.
No takes yet. Share an insight, caveat, or question.
HDL-C may refine CV mortality risk stratification only without CAD; leaves open its prognostic role in established disease.
Silbernagel et al. (2013) conducted a cohort in Coronary artery disease (n=3,141). High-density lipoprotein (HDL) cholesterol vs. 1st tertile of HDL cholesterol was evaluated on Cardiovascular mortality (HR 0.37, 95% CI 0.18-0.74, p=0.005). Higher HDL cholesterol was associated with lower cardiovascular mortality in people without CAD (HR 0.37; 95% CI 0.18-0.74), but this relationship was not significant in patients with CAD.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: