Why the study?
Is a marked reduction in plasma cholesterol associated with impaired cardiac function following heart transplantation?
Is a marked reduction in plasma cholesterol associated with impaired cardiac function following heart transplantation?
An unexpected, marked reduction in total cholesterol late after heart transplantation may signal a decline in allograft left ventricular function and should prompt assessment.
Marked cholesterol reduction was associated with LV decline post-transplant; leaves open causality and need for prospective studies.
During follow-up of 59 cardiac transplant recipients over 2 or more years, a small group of subjects was observed who displayed an unpredictable, relatively marked, reduction in plasma cholesterol. 2. A significant proportion of these subjects were subsequently observed as having experienced a marked decline in left ventricular function at the time of routine radionuclide ventriculography. 3. While the mechanism for this fall in cholesterol is unclear, the observation of such an unexpected reduction in total cholesterol, late after heart transplantation should be considered significant and prompt further investigation including an assessment of allograft function.
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Kaye et al. (1994) studied this question.
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