What question did this study set out to answer?

To evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) as primary therapy for prostate cancer and define optimal indications in clinical practice.

March 5, 2008BJU International

High‐intensity focused ultrasound in prostate cancer; a systematic literature review of the French Association of Urology

View Full Paper

Ask AI

Bookmark

To evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) as primary therapy for prostate cancer and define optimal indications in clinical practice.
Systematic review of Medline, Embase (through July 2007), and EAU/AUA annual meeting abstracts (2005–2007).
Analyzed 37 case series evaluating primary HIFU in patients aged approximately 70 years with T1–T2 N0M0 disease, Gleason score ≤7, PSA ≤28 ng/mL, and prostate volume ≤40 mL.
Negative post-treatment biopsy rates ranged from 64% to 93%, with a PSA nadir ≤0.5 ng/mL reached in 55% to 84% of patients.
Actuarial 5-year disease-free survival rates ranged between 60% and 70%.
Common adverse events included stress urinary incontinence, urinary tract infection, bladder neck or urethral strictures, and erectile dysfunction, with incidence decreasing after device refinements and preceding transurethral resection.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Systematic review demonstrates effective cancer control with high-intensity focused ultrasound in older men with localized prostate cancer, indicating suitability for select low-risk cases.

Cite This Study

Rébillard et al. (2008) studied this question.

synapsesocial.com/papers/6a7deb654776ec6335187b67 https://doi.org/10.1111/j.1464-410x.2008.07504.x

View Full Paper

Ask AI

Bookmark

Implication

Systematic review demonstrates effective cancer control with high-intensity focused ultrasound in older men with localized prostate cancer, indicating suitability for select low-risk cases.

High‐intensity focused ultrasound in prostate cancer; a systematic literature review of the French Association of Urology

Key Points

Discussion

Implication

Cite This Study

High‐intensity focused ultrasound in prostate cancer; a systematic literature review of the French Association of Urology

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider