What question did this study set out to answer?

To assess the efficacy and safety of azathioprine and subsequent methotrexate in inducing and maintaining clinical remission in steroid-dependent or steroid-resistant active ulcerative colitis.

September 19, 2002Alimentary Pharmacology & TherapeuticsOpen Access

Azathioprine or methotrexate in the treatment of patients with steroid‐dependent or steroid‐resistant ulcerative colitis: results of an open‐label study on efficacy and tolerability in inducing and maintaining remission

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Authors

OPOmero Alessandro PaoluziPoliclinico Tor Vergata RPRoberta PicaMercy Medical Center AMAdriana MarcheggianoSapienza University of Rome

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Implication

Open-label study reveals durable remission with methotrexate in steroid-dependent ulcerative colitis, highlighting its effectiveness when azathioprine fails.

Key Points

To assess the efficacy and safety of azathioprine and subsequent methotrexate in inducing and maintaining clinical remission in steroid-dependent or steroid-resistant active ulcerative colitis.
Conducted an open-label trial involving 42 patients with active steroid-dependent or steroid-resistant ulcerative colitis treated with oral azathioprine (2 mg/kg daily).
Switched patients with azathioprine intolerance or resistance to intramuscular methotrexate (12.5 mg/week), assessing therapeutic efficacy clinically, endoscopically, and histologically at 6 months.
Azathioprine induced complete remission in 22 of 32 evaluable patients (69%), improvement in 6 (19%), and no benefit in 4 (12%), while 10 of the original 42 patients discontinued early due to adverse effects.
Methotrexate induced complete remission in 6 of 10 patients (60%) and improvement in 4 of 10 patients (40%) who failed or could not tolerate azathioprine.
During long-term maintenance, significantly fewer patients on methotrexate experienced disease relapse compared to those on azathioprine [2/10 (20%) vs. 16/28 (57%), P < 0.05].

Cite This Study

Paoluzi et al. (2002) studied this question.

synapsesocial.com/papers/6a7ded2f3fa445558d7d8cfe https://doi.org/10.1046/j.1365-2036.2002.01340.x

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Implication

Open-label study reveals durable remission with methotrexate in steroid-dependent ulcerative colitis, highlighting its effectiveness when azathioprine fails.

Azathioprine or methotrexate in the treatment of patients with steroid‐dependent or steroid‐resistant ulcerative colitis: results of an open‐label study on efficacy and tolerability in inducing and maintaining remission

Discussion

Member takes

Implication

Key Points

Cite This Study

Azathioprine or methotrexate in the treatment of patients with steroid‐dependent or steroid‐resistant ulcerative colitis: results of an open‐label study on efficacy and tolerability in inducing and maintaining remission

Discussion

Member takes

Implication

Key Points

Cite This Study

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