Trimethylsilyl cyanide was found to react with Schiff bases and oximes in the presence of a catalytic amount of Lewis acids to afford N-trimethylsilyl-α-aminonitriles and N-trimethylsilyloxy-α-aminonitriles in excellent yields, which were easily hydrolyzed to the corresponding α-aminonitriles and α-hydroxyaminonitriles.
No takes yet. Share an insight, caveat, or question.
Ojima et al. (1975) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: