Key Points
- Assess the clinical relationship between obesity and coronary artery disease while evaluating the validity of the reported obesity paradox across various clinical settings.
- Narrative review of contemporary epidemiological data, clinical outcomes, and population-based registry evidence linking obesity to cardiovascular morbidity.
- Evaluation of confounding biases and contradictory findings reported in clinical cohorts undergoing coronary intervention.
- Population-based registries demonstrate that overweight and obese patients account for 43% and 24% of all coronary revascularization procedures, respectively.
- Morbid obesity consistently correlates with elevated risks of hypertension, hyperlipidemia, and diabetes mellitus, while conflicting observational reports paradoxically describe improved survival among certain overweight cohorts.
Structured PICO
PPopulationOverweight and obese patients with coronary artery disease
The review highlights the ongoing debate and conflicting evidence regarding the existence of an 'obesity paradox' in coronary artery disease outcomes.