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August 24, 2018The Journal of Clinical Endocrinology & MetabolismOpen Access

Obesity as a Key Factor Underlying Idiopathic Hyperaldosteronism

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Population

1,805 patients, including 516 with aldosterone-producing adenoma, 1,015 with idiopathic hyperaldosteronism…

Design

Cross-sectional

Authors

YOYouichi OhnoKyoto UniversityMSMasakatsu SoneSt. Marianna University School of MedicineNINobuya InagakiKitano Hospital

Discussion

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Implication

Highlights need for subtype-specific evaluation in primary aldosteronism; hypothesis-generating for obesity's role in IHA pathogenesis.

Structured PICO

P
Population
1,805 patients, including 516 with aldosterone-producing adenoma (APA), 1,015 with idiopathic hyperaldosteronism (IHA), and 274 with essential hypertension (EHT) from the multicenter Japan Primary Aldosteronism Study.
O
Outcome
Prevalences of obesity and metabolic disorders

Idiopathic hyperaldosteronism is strongly associated with obesity compared to aldosterone-producing adenoma, suggesting a distinct obesity-related pathogenesis.

Cite This Study

Ohno et al. (2018) studied this question.

synapsesocial.com/papers/6a7def707bc3bc414599b60dhttps://doi.org/10.1210/jc.2018-00866

Topics

Lipid management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies2004 · 12,909 citations
  2. 2Body Mass Index Predicts Plasma Aldosterone Concentrations in Overweight-Obese Primary Hypertensive Patients2008 · 190 citations
  3. 3A possible association between primary aldosteronism and a lower β-cell function2007 · 95 citations
  4. 4Concurrent primary aldosteronism and subclinical cortisol hypersecretion2011 · 62 citations
  5. 5Prevalence and Characteristics of the Metabolic Syndrome in Primary Aldosteronism2006 · 373 citations