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March 27, 2025MetabolitesOpen Access

Metabolic Profiling Reveals Potential Prognostic Biomarkers for SFTS: Insights into Disease Severity and Clinical Outcomes

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Why the study?

Severe fever with thrombocytopenia syndrome has an increasing prevalence and an approximately 10% case fatality rate, but its underlying pathogenic mechanisms remain poorly understood, limiting therapeutic development.

Can metabolic biomarkers predict disease severity and clinical outcomes in patients with SFTS?

Population

78 SFTS patients during the acute phase of illness

Comparison

Survival vs fatal cases

Authors

ZZZhuo-Min ZhuHLHuan-Yu LiuNANa AnHarbin Medical University

Discussion

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Implication

Elevated phenyllactic and isocitric acid may aid early SFTS risk stratification; leaves open prospective validation before clinical adoption.

Structured PICO

Can metabolic biomarkers predict disease severity and clinical outcomes in patients with SFTS?

P
Population
78 patients with Severe fever with thrombocytopenia syndrome (SFTS) during the acute phase of illness
I
Intervention
Untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) and metabolic prognostic model
C
Comparator
Survival vs fatal cases
O
Outcome
Prediction of disease severity and fatal outcomes based on metabolic biomarkerssurrogate

Metabolic profiling identified phenyllactic acid and isocitric acid as potential prognostic biomarkers for predicting disease severity in SFTS patients.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/6a7df0674776ec6335187c35https://doi.org/10.3390/metabo15040228
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sphingosine 1-Phosphate in Acute Dengue Infection2014 · 52 citations
  2. 2Metabolic analysis as a driver for discovery, diagnosis, and therapy2022 · 185 citations
  3. 3Cellular metabolism of myeloid cells in sepsis2016 · 123 citations
  4. 4Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China2011 · 2,002 citations
  5. 5Severe Fever with Thrombocytopenia Syndrome, Japan, 2013–20172020 · 210 citations