Long term fenofibrate did not reduce major coronary events but may reduce total CVD events in type 2 diabetes

Keech A, Simes RJ, Barter P, et al . Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005;366:1849–61. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In patients with type 2 diabetes mellitus, what is the effect of long term fenofibrate therapy on coronary heart disease (CHD) events? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Geriatrics ★★★★★☆☆ ### ![Graphic][5]Design randomised placebo-controlled trial (Fenofibrate Intervention and Event Lowering in Diabetes [FIELD]). ### ![Graphic][6]Allocation concealed.* ### ![Graphic][7]Blinding blinded (clinicians, patients, and outcome assessors).* ### ![Graphic][8]Follow up period median 5 years. ### ![Graphic][9]Setting 63 centres in Australia, New Zealand, and Finland. ### ![Graphic][10]Patients 9795 patients 50–75 years of age (mean age 62 y, 63% men) who had a World Health Organization diagnosis of type 2 diabetes, total cholesterol concentration 3–6.5 mmol/l, and a total cholesterol/high density lipoprotein (HDL) cholesterol ratio ⩾4 or a triglyceride concentration of 1–5 mmol/l, with no clear indication for lipid modifying therapy. Exclusion criteria were renal impairment, chronic liver disease, symptomatic gallbladder disease, or occurrence of a cardiovascular disease (CVD) event within 3 months … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DKeech%26rft.auinit1%253DA.%26rft.volume%253D366%26rft.issue%253D9500%26rft.spage%253D1849%26rft.epage%253D1861%26rft.atitle%253DEffects%2Bof%2Blong-term%2Bfenofibrate%2Btherapy%2Bon%2Bcardiovascular%2Bevents%2Bin%2B9795%2Bpeople%2Bwith%2Btype%2B2%2Bdiabetes%2Bmellitus%2B%2528the%2BFIELD%2Bstudy%2529%253A%2Brandomised%2Bcontrolled%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252805%252967667-2%26rft_id%253Dinfo%253Apmid%252F16310551%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(05)67667-2&link_type=DOI [3]: /lookup/external-ref?access_num=16310551&link_type=MED&atom=%2Febmed%2F11%2F3%2F86.atom [4]: /lookup/external-ref?access_num=000233643200023&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif