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February 15, 1994Proceedings of the National Academy of SciencesOpen Access

Regulation of metallothionein genes by heavy metalsappears to be mediated by a zinc-sensitive inhibitor that interacts with aconstitutively active transcription factor, MTF-1.

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Richard D. Palmiter
Richard D. PalmiterHoward Hughes Medical Institute

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Richard D. Palmiter (1994) studied this question.

synapsesocial.com/papers/6a7df136143763190a3ca00ehttps://doi.org/10.1073/pnas.91.4.1219
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-l gene and variant sequences1990 · 67 citations
  2. 2Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.1988 · 176 citations
  3. 3Metallothionein and other cadmium-binding proteins: recent developments1990 · 206 citations
  4. 4Glucocorticoid regulation of metallothionein-I mRNA synthesis in cultured mouse cells.1981 · 210 citations
  5. 5Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter.1987 · 89 citations