December 1, 1993Journal of VirologyOpen Access

Processing of pestivirus polyprotein: cleavage site between autoprotease and nucleocapsid protein of classical swine fever virus

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Population

Classical swine fever virus (cell-free transcription-translation system and expression systems)

Design

Preclinical

Authors

Discussion

Hypothesis-generating for CSFV antivirals; leaves open validation in natural hosts before any translational consideration.

Population

Classical swine fever virus (cell-free transcription-translation system and expression systems)

Intervention

Expression of genomic regions and successive truncation of cDNA

Outcome

Determination of the proteolytic cleavage site between p23 and p14

Identifies the specific cleavage site (Cys-168 and Ser-169) between the autoprotease and nucleocapsid protein in classical swine fever virus.

Stark et al. (1993) studied this question.

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