Why the study?
Does knowledge of genetic variation at chromosome 9p21.3 improve cardiovascular disease risk prediction beyond traditional risk factors in healthy white women?
Population
22,129 female white health professionals in the United States participating in the Women's Genome Health…
Comparison
Addition of chromosome 9p21.3 genetic variation… vs Risk prediction model based on traditional risk…
Design
Cohort
Follow-up
median 10.2 years
Authors
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Genotype at 9p21.3 adds no value to CVD risk prediction in women; leaves open whether expanded genetic panels improve models beyond traditional factors.
Does knowledge of genetic variation at chromosome 9p21.3 improve cardiovascular disease risk prediction beyond traditional risk factors in healthy white women?
Although genetic variation at chromosome 9p21.3 is associated with incident cardiovascular disease, it does not improve risk prediction beyond traditional risk factors.
Nina P. Paynter (2009) studied this question.
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