What question did this study set out to answer?

To determine the routes and timing of Candida albicans acquisition among hospitalized infants in a neonatal intensive care unit.

May 1, 1998Journal of Clinical MicrobiologyOpen Access

Nonperinatal Nosocomial Transmission of Candida albicans in a Neonatal Intensive Care Unit: Prospective Study

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Authors

SRSusan E. ReefUniversity of New Caledonia BLBrent A. LaskerCenters for Disease Control and Prevention DBDona S. ButcherGrady Memorial Hospital

Discussion

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Implication

Prospective study reveals nonperinatal nosocomial transmission of Candida albicans in neonatal intensive care units, indicating environmental acquisition drives infant colonization and infection.

Key Points

To determine the routes and timing of Candida albicans acquisition among hospitalized infants in a neonatal intensive care unit.
Conducted prospective surveillance culturing infants at birth (mouth, umbilicus, groin) and weekly until discharge, alongside maternal cultures at delivery (mouth, vagina).
Evaluated molecular relatedness of 49 C. albicans isolates using restriction endonuclease analysis and restriction fragment length polymorphism hybridized with the CARE-2 probe.
All infants were culture-negative at birth, but 6 acquired C. albicans during their hospital stay; 34 of 64 mothers (53%) were culture-positive at delivery.
Isolates from all four colonized mother-infant pairs displayed discordant genomic hybridization profiles, while one infant developed candidemia from an isolate identical to their colonizing strain.

Cite This Study

Reef et al. (1998) studied this question.

synapsesocial.com/papers/6a7df468699b737ada99a3c4 https://doi.org/10.1128/jcm.36.5.1255-1259.1998

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Implication

Prospective study reveals nonperinatal nosocomial transmission of Candida albicans in neonatal intensive care units, indicating environmental acquisition drives infant colonization and infection.

Nonperinatal Nosocomial Transmission of Candida albicans in a Neonatal Intensive Care Unit: Prospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Nonperinatal Nosocomial Transmission of Candida albicans in a Neonatal Intensive Care Unit: Prospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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