Hyperlipidemia and Pancreatitis during Pregnancy in Two Sisters with a Mutation in the Lipoprotein Lipase Gene

2 sisters of French Canadian ancestry with acute pancreatitis, acute respiratory distress syndrome, and severely elevated triglyceride levels associated with pregnancy (one in last trimester, one 1 month postpartum).

Medical stabilization with fat restriction, surgical stabilization (1 patient), followed by fat restriction, weight loss, and gemfibrozil; DNA sequencing.

Detection of genetic mutation via DNA sequencingsurrogate