Alkalinization of the Urine and Lowering of Urine Uric Acid Content in Diabetic Patients with a Low Urine PH Results in Prevention and Dissolution of Uric Acid Stones - A Case Report and A Retrospective Outcome Study

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With insulin resistance there is a decreased production of ammonia in the proximal tubule of the kidney leading to a low urinary PH which results in precipitation of uric acid crystals which form the nidus for the formation of a uric acid kidney stone. Alkalinization of the urine and lowering of the urine uric acid levels can prevent formation of these stones as well as causing dissolution of existing stones. In this report we describe a patient who prior to this intervention had at least 130 events related to kidney stones and who following intervention had no further events. In addition, we describe a retrospective survey of outcomes of this intervention in twelve subjects with multiple kidney stone related events. There was no recurrence of events related to kidney stones in this group. Therefore, alkalinization of the urine and lowering of uric acid content in diabetic patients with a low urine PH is extremely effective in avoiding further kidney stone related events.