What question did this study set out to answer?

To evaluate whether cerebrospinal fluid acetylcholine and choline concentrations differ across patients diagnosed with Alzheimer disease, dementia with Lewy bodies, and neurological controls.

October 22, 2025Journal of Alzheimer s Disease

Cerebrospinal fluid acetylcholine is not a reliable diagnostic marker for Alzheimer's disease and dementia with Lewy bodies

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Authors

CAClément AveneauDélégation Paris 5 ELElodie LamyInserm SGStanislas Grassin‐DelyleInserm

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Implication

Randomized trial reveals unaltered cerebrospinal fluid acetylcholine levels in neurodegenerative dementia, suggesting its limited utility as a diagnostic biomarker.

Key Points

To evaluate whether cerebrospinal fluid acetylcholine and choline concentrations differ across patients diagnosed with Alzheimer disease, dementia with Lewy bodies, and neurological controls.
Included patients with Alzheimer disease (n = 149), dementia with Lewy bodies (n = 20), and neurological controls (n = 45) from the CHOLINE study (NCT03090854) or locoregional anesthesia procedures.
Measured cerebrospinal fluid acetylcholine and choline concentrations using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), and evaluated acetylcholinesterase activity via an enzymatic assay.
Evaluated differences between diagnostic groups using multivariate linear regression adjusted for age, sex, and cardiovascular risk factors.
No statistically significant differences in cerebrospinal fluid acetylcholine or choline concentrations were observed between the diagnostic groups.
Acetylcholinesterase activity differed significantly across groups (p = 0.03), showing lower enzymatic activity in dementia with Lewy bodies compared to Alzheimer disease and neurological controls.

Cite This Study

Aveneau et al. (2025) studied this question.

synapsesocial.com/papers/6a7df74ec2b228f3e18caa76 https://doi.org/10.1177/13872877251387159

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Implication

Randomized trial reveals unaltered cerebrospinal fluid acetylcholine levels in neurodegenerative dementia, suggesting its limited utility as a diagnostic biomarker.

Cerebrospinal fluid acetylcholine is not a reliable diagnostic marker for Alzheimer's disease and dementia with Lewy bodies

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebrospinal fluid acetylcholine is not a reliable diagnostic marker for Alzheimer's disease and dementia with Lewy bodies

Discussion

Member takes

Implication

Key Points

Cite This Study

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