Primary cutaneous carcinosarcoma developing after chronic C-arm radiation exposure

Malignancy can develop after exposure to ionizing radiation. Basal cell carcinoma, squamous cell carcinoma (SCC), and sarcoma associated with ionizing radiation have been reported previously1,2; however, cases of ionizing radiation–induced carcinosarcoma (CS) are rare.3 CS is a biphasic tumor with overt carcinomatous and sarcomatous features apparent with both light microscopy and immunohistochemistry.4 Here, a case of primary cutaneous carcinosarcoma (PCCS) after chronic occupational exposure to ionizing radiation is presented.