Why the study?
Does sesamin prevent cardiac remodeling and hypertrophy in mice subjected to transverse aortic constriction?
Population
Mice subjected to transverse aortic constriction (TAC) or sham surgery
Comparison
Sesamin 100 mg/kg/day via oral gavage for 3… vs Vehicle
Design
Preclinical
Follow-up
3 weeks
Authors
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Sesamin supports Sirt3-dependent remodeling protection in TAC mice; hypothesis-generating for human cardiac hypertrophy, should not change practice.
Does sesamin prevent cardiac remodeling and hypertrophy in mice subjected to transverse aortic constriction?
Sesamin demonstrates protective effects against cardiac remodeling and hypertrophy in a preclinical pressure-overload model via the Sirt3/ROS pathway.
Fan et al. (2017) studied this question.
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