Why the study?
Does 12-week voluntary exercise improve cardiac performance and alter gene expression in 20-month-old male and female Wistar rats?
Does 12-week voluntary exercise improve cardiac performance and alter gene expression in 20-month-old male and female Wistar rats?
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Voluntary exercise improves cardiac function and alters key cardiovascular gene expression in aged rats, highlighting potential molecular mechanisms for exercise-induced cardioprotection with notable sex differences.
Voluntary exercise has proved to be an effective therapeutic tool to improve cardiac function in aged rats with clearly visible sex differences. Long-term exercise is associated with decreased Ogn and Comt expression and enhanced presence of Pcp4 and Esm1 genes. Sex-dependent changes were also observed in the expression of the cardiovascular key proteins. Fundamental alterations in gene and protein expression may contribute to the improvement of cardiac performance.
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Börzsei et al. (2020) studied this question.
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