What question did this study set out to answer?

Review the biological mechanisms, structural properties, and clinical performance of synthetic and xenogenic bone graft substitutes used in orthopedic surgery.

January 1, 2018New Journal of Glass and CeramicsOpen Access

Current Concepts in Bone Graft Substitutes

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Review the biological mechanisms, structural properties, and clinical performance of synthetic and xenogenic bone graft substitutes used in orthopedic surgery.
Evaluated the role of macroporosity, pore interconnectivity, and internal surface area across synthetic calcium phosphates and xenografts.
Assessed preclinical and clinical evidence on the osteoconductive, osteoinductive, and osteointegrative behaviors of nonhuman bony scaffolds.
Optimal bone regeneration relies on scaffold macroporosity combined with autologous host cells and growth factors to establish osteoinductive and osteoconductive environments.
Highly processed bovine hydroxyapatites exhibit superior pore accessibility and internal surface exposure compared to autografts, allografts, and synthetics.
Processed xenograft matrices provide durable structural conductivity and extended mechanical stability across complex orthopedic defect reconstructions.

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Implication

Review demonstrates structural advantages of bovine hydroxyapatite in orthopedic bone defects, highlighting enhanced macroporosity and long-term stability.

Cite This Study

Leteve et al. (2018) studied this question.

synapsesocial.com/papers/6a7dfaaa29cd345315cda7f7 https://doi.org/10.4236/njgc.2018.83004

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Implication

Review demonstrates structural advantages of bovine hydroxyapatite in orthopedic bone defects, highlighting enhanced macroporosity and long-term stability.

Current Concepts in Bone Graft Substitutes

Key Points

Discussion

Implication

Cite This Study

Current Concepts in Bone Graft Substitutes

Key Points

Discussion

Implication

Cite This Study

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