Why the study?
Is baseline LDL-c associated with suicidal behaviour in patients with first-episode psychosis?
Is baseline LDL-c associated with suicidal behaviour in patients with first-episode psychosis?
Lower LDL-c levels may serve as a biological marker associated with an increased risk of suicidal behaviour in patients with first-episode psychosis.
May flag suicide risk in first-episode psychosis; hypothesis-generating and requires prospective validation before any clinical use.
OBJECTIVES: Our aims were to confirm the relationship between lipid and lipoprotein concentrations and suicidal behaviour in first-episode psychosis (FEP) patients. METHODS: Suicidal behaviour was explored in a large FEP sample (N = 383). Baseline lipid profile was compared between those who attempted or completed suicide and those who not presented suicidal behaviour. RESULTS: Low-density lipoprotein cholesterol (LDL-c) (OR = 0.99, 95% CI= 0.98-1.00) and depressive symptoms (OR = 1.15, 95% CI = 1.06-1.24) were significantly related with suicidal behaviour. CONCLUSIONS: Lipid profile test may be considered in the assessment of suicide risk in psychosis and LDL-c an important biological marker.
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Ayesa‐Arriola et al. (2017) studied this question.
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