The identification of a specific IL1 beta binding protein in human plasma suggests it may act as an important carrier molecule for IL1 beta in vivo.
May act as IL-1β carrier in plasma; hypothesis-generating for its role in cytokine regulation.
A covalent cross-linking technique was used to bind iodinated interleukin-1 (IL1) alpha and beta to plasma proteins. One specific IL1 beta binding protein was observed, that when cross-linked to 125I-IL1 beta migrated to approximately 60 kDa on SDS-PAGE. The protein did not bind IL1 alpha. The 43 -kDa protein was partially purified using a wheat germ agglutinin affinity column. The isolated factor again specifically bound IL1 beta, and appeared to consist of single chain glycoprotein. The protein was heat stable and had a rapid association time with IL1 beta. This protein may be an important carrier molecule for IL1 beta in vivo.
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Eastgate et al. (1990) studied this question.
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