Passage of albumin from cerebrospinal fluid to blood plasma was determined in anesthetized dogs by injecting radio-iodinated human serum albumin into the cisterna magna and monitoring the plasma radioactivity. An equilibrium time of 16-20 hours was obtained. Radioactive colloidal gold injected intrathecally was not detectable in the general circulation in 24 hours and appeared to be well localized within the cerebral fluid space.
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Wart et al. (1960) studied this question.