Why the study?
Does systemic VEGF inhibition accelerate atherosclerosis in apolipoprotein E knockout mice?
Population
Eight-week old apolipoprotein E knockout mice on a high-cholesterol diet for 24 weeks, and cultured human…
Comparison
Systemic pan-VEGF receptor inhibitor via gavage… vs Placebo (gavage)
Design
Preclinical
Follow-up
10 weeks
Authors
Loading...
May accelerate atherosclerosis with VEGF inhibition in mice; leaves open translation to CV risk with anti-angiogenic therapies in humans.
Does systemic VEGF inhibition accelerate atherosclerosis in apolipoprotein E knockout mice?
Systemic VEGF inhibition accelerates atherosclerosis and disrupts endothelial homeostasis in experimental models, providing a mechanistic basis for the cardiovascular adverse effects of anti-angiogenic therapies.
Winnik et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: