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Interference with the binding of coagulation factor X to adenoviral vectors may make them safer and more effective by reducing innate immune responses.
Human adenovirus (HAd)-based vectors are notorious for their ability to induce profound innate immune responses, causing liver damage and even lethal circulatory collapse. In a recent issue of Science, Doronin et al.1 now show that one of the ways by which adenoviruses trigger the innate immune response is through the binding of coagulation factor X (FX), a phylogenetically ancient component of the blood clotting system. Interference with this process may therefore make adenoviral vectors both safer and more effective.
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Suzuki et al. (2012) studied this question.
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