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July 15, 2026PLoS PathogensOpen Access

Structural requirements of blood factors binding to soluble hexon trimers with implications for adenovirus cell targeting and immune evasion

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Authors

XOX. OliviaUniversity of MinnesotaSLShao‐Chia LuMayo ClinicHMHaley MudrickMayo Clinic

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Overview

Randomized trial evaluates blood factor binding in adenovirus variants, suggesting new targeting strategies.

Key Points

  • This research aims to define the structural basis of serotype-specific host factor recognition by adenoviruses.
  • Determined high-resolution cryo-electron microscopy structures of hexon trimers from HAdV-C5 and HAdV-C6.
  • Analyzed binding interactions with coagulation factors FX and prothrombin (FII).
  • Compared structural differences in hexon complexes between serotypes C and D.
  • HAdV-C5 hexon preferentially binds coagulation factor X (FX), while HAdV-C6 favors prothrombin (FII).
  • HAdV-D26 hexon does not bind any coagulation factor due to structural constraints.
  • Identified conserved binding interfaces that facilitate serotype-specific interactions with coagulation factors.

Cite This Study

Olivia et al. (2026) studied this question.

synapsesocial.com/papers/6a5722be88b21df87547fa11https://doi.org/10.1371/journal.ppat.1014389
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure-derived insights from blood factors binding to the surfaces of different adenoviruses2024 · 8 citations
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  5. 5Gctf: Real-time CTF determination and correction2015 · 4,162 citations