November 16, 2007Blood

Dose-Dependent Antithrombotic Effects of Apixaban, an Oral Direct Factor Xa Inhibitor, in Prevention and Treatment of Thrombosis in Rabbit Models of Arteriovenous-Shunt and Venous Thrombosis at Doses That Preserve Hemostasis.

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Population

Rabbit models of arteriovenous-shunt thrombosis, venous thrombosis, and cuticle bleeding time.

Comparison

Apixaban. vs Lepirudin, fondaparinux, and warfarin.

Design

Preclinical

Authors

PWPancras C. WongPreventive Cardiology ECEarl J. CrainBristol-Myers Squibb (Germany)DPDonald PintoBristol-Myers Squibb (United States)

Discussion

Member takes

Implication

Should not change practice; hypothesis-generating for apixaban's hemostatic profile in humans.

Structured PICO

Population

Rabbit models of arteriovenous-shunt thrombosis (AVST), venous thrombosis (VT), and cuticle bleeding time (BT) (n=6 per group).

Intervention

Apixaban (0.03 to 3 mg/kg/h IV for prevention; 0.6 mg/kg bolus + 0.87 mg/kg/h IV infusion for treatment).

Comparator

Lepirudin (0.006 to 0.75 mg/kg/h IV), fondaparinux (0.01 to 1 mg/kg/h IV), and warfarin (0.1 to 3 mg/kg/day PO).

Outcome

Thrombus weight and cuticle bleeding time (BT).surrogate

In rabbit models, apixaban demonstrated effective prevention and treatment of thrombosis with a more favorable hemostatic profile compared to warfarin and lepirudin.

Cite This Study

Wong et al. (2007) studied this question.

synapsesocial.com/papers/6a7e037530df0be8fb5ca357 https://doi.org/10.1182/blood.v110.11.933.933

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Dose-Dependent Antithrombotic Effects of Apixaban, an Oral Direct Factor Xa Inhibitor, in Prevention and Treatment of Thrombosis in Rabbit Models of Arteriovenous-Shunt and Venous Thrombosis at Doses That Preserve Hemostasis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dose-Dependent Antithrombotic Effects of Apixaban, an Oral Direct Factor Xa Inhibitor, in Prevention and Treatment of Thrombosis in Rabbit Models of Arteriovenous-Shunt and Venous Thrombosis at Doses That Preserve Hemostasis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider