Why the study?
Does r-hirudin or DX9065a inhibit clot-bound thrombin and prothrombinase in human clots?
Does r-hirudin or DX9065a inhibit clot-bound thrombin and prothrombinase in human clots?
In an in vitro human clot model, the factor Xa inhibitor DX9065a blocks prothrombin activation but not clot-bound thrombin, whereas the direct thrombin inhibitor hirudin blocks thrombin activity but not prothrombin activation.
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In vitro differences between hirudin and DX9065a do not support practice change; leaves open combined inhibition strategies in thrombosis.
Meddahi et al. (2005) studied this question.
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