Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study
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Population
680 Caucasian and African-American adults from a community-based cohort attending the 25-year follow-up exam…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports CV risk monitoring for brain health in middle age; leaves open causality and prevention effects.
Key Points
- To identify early alterations in brain structure, perfusion, and cognitive function associated with cardiovascular risk factors in midlife adults.
- Cross-sectional 3T brain MRI evaluation conducted at three U.S. sites during the 25-year follow-up of the CARDIA study (N=680 Caucasian and African-American participants, mean age 50.3 years).
- Quantified total brain volume (TBV), abnormal white matter (AWM) volume, white matter fractional anisotropy (WM-FA), gray matter cerebral blood flow (GM-CBF), and Global Cognitive Function (GCF) scores.
- Current smoking was significantly associated with lower GM-CBF, lower TBV, and higher AWM (all p<0.05), while hypertension was associated with lower GM-CBF, lower WM-FA, lower TBV, and higher AWM (all p<0.05).
- Higher BMI was associated with lower GM-CBF (p<0.003), diabetes with lower TBV (p=0.007), and lower global cognitive scores correlated with reduced TBV, elevated AWM, and altered WM-FA (all p<0.01).
Structured PICO
P
Population
680 Caucasian and African-American adults (mean age 50.3 years, 52.2% female, 39.4% Black) from a community-based cohort attending the 25-year follow-up exam of the Coronary Artery Risk Development in Young Adults (CARDIA) Study in three US sites.
O
Outcome
Quantitative estimates of total brain volume (TBV), abnormal white matter (AWM) volume, white matter fractional anisotropy (WM-FA), and gray matter cerebral blood flow (GM-CBF) measured by 3T brain MRI.surrogate
In middle-aged adults, cardiovascular risk factors are associated with early adverse changes in brain structure, perfusion, and cognitive function, highlighting the importance of early risk factor modification.
Limitations
- Cross-sectional study design
Cite This Study
Launer et al. (2015) studied this question.
Topics
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