The study identifies intertypic recombination between HEV71 and CV-A16 in isolates from HFMD patients, suggesting a mechanism for the emergence of new HEV71 lineages.
Recombinant HEV71 strains in HFMD may signal emerging variants; leaves open effects on virulence or transmission pending larger studies.
Hand, foot and mouth disease (HFMD) is a common illness of infants and young children <10 years of age. It is characterized by fever, ulcers in the oral cavity, and rashes with blisters that appear on the palm and sole. The most common causal agents of HFMD are coxsackievirus A16 (CV-A16) and human enterovirus 71 (HEV71), but other enteroviruses, including CV-A5 and CV-A10, can also cause it. When caused by CV-A16 infection, it is usually a mild disease, and patients normally recover without requiring any special medical attention.
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Yoke Fun Chan (2004) studied this question.
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