Key result
There is an urgent need for a globally representative, multivalent vaccine against hand, foot, and mouth disease in Malaysia due to the changing epidemiology and emergence of non-EV71 serotypes.
Highlights the changing epidemiology of HFMD in Malaysia and the need for a multivalent vaccine covering major enterovirus serotypes.
Hand, foot, and mouth disease (HFMD) is a contagious viral infection, which commonly affects young children under five years of age (Yu et al., 2019). HFMD is caused by serotypes of the Enterovirus A species, particularly enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), in the genus Enterovirus (Takahashi et al., 2016). Symptoms of HFMD usually include fever, sore throat and maculopapular or vesicular rashes on hands, feet and mouth, which resolve spontaneously. On the other hand, severe HFMD, which is often associated with EV71 infection, can lead to life-threatening cardiopulmonary and neurologic complications (Xu et al., 2015).
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Siat Yee Fong (2023) conducted an editorial in Hand, Foot, and Mouth Disease (HFMD). Multivalent HFMD Vaccine was evaluated. There is an urgent need for a globally representative, multivalent vaccine against hand, foot, and mouth disease in Malaysia due to the changing epidemiology and emergence of non-EV71 serotypes.
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