April 19, 2007Proteins Structure Function and BioinformaticsOpen Access

Drug block of the hERG potassium channel: Insight from modeling

View Full Paper

Ask AI

Bookmark

Population

Structural models of the human ether-a-go-go-related gene (hERG) K(+) channel pore domain

Design

Preclinical

Authors

PSPhillip J. StansfeldCentre for Human Genetics PGPeter GedeckCollaborative Drug Discovery (United States)MGMartin GoslingEnterprise Sciences (United States)

Discussion

Member takes

Implication

Refined structural models of the hERG channel pore domain provide insights into the binding of diverse drugs, aiding in the prediction of acquired long QT syndrome risk.

Structured PICO

Population

Structural models of the human ether-a-go-go-related gene (hERG) K(+) channel pore domain

Intervention

Docking a set of 20 hERG blockers and refining the model by rotating the S6 transmembrane helix and enlarging the cavity

Outcome

Agreement of modeled complexes with site-directed mutagenesis data

Refined structural models of the hERG channel pore domain provide insights into the binding of diverse drugs, aiding in the prediction of acquired long QT syndrome risk.

Cite This Study

Stansfeld et al. (2007) studied this question.

synapsesocial.com/papers/6a7e07c1968fa26fcacb570d https://doi.org/10.1002/prot.21400

View Full Paper

Ask AI

Bookmark

Implication

Refined structural models of the hERG channel pore domain provide insights into the binding of diverse drugs, aiding in the prediction of acquired long QT syndrome risk.

Drug block of the hERG potassium channel: Insight from modeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Drug block of the hERG potassium channel: Insight from modeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider