Why the study?
Does CGRP-induced vasodilation depend on nitric oxide, prostaglandins, or potassium channels in healthy subjects?
Population
40 healthy subjects
Comparison
Intrabrachial infusion of calcitonin… vs Intrabrachial infusion of CGRP coinfused with…
Design
Other
Follow-up
Acute (during infusion)
Authors
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Implicates NO in CGRP vasodilation among healthy subjects; leaves open relevance to disease states or targeted therapies.
Does CGRP-induced vasodilation depend on nitric oxide, prostaglandins, or potassium channels in healthy subjects?
CGRP-induced vasodilation in humans is partially dependent on nitric oxide release but does not involve prostaglandins or calcium/ATP-sensitive potassium channels.
DEHOON et al. (2003) studied this question.
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