A Ruthenium(II) Complex with a C₂-Symmetric Diphosphine/Diamine Tetradentate Ligand for Asymmetric Transfer Hydrogenation of Aromatic Ketones

The trans -Ru II Cl 2 complexes with structurally similar N, N ‘-bis[ o -(diphenylphosphino)benzylidene]cyclohexane-1,2-diamine and N, N ‘-bis[ o -(diphenylphosphino)benzyl]cyclohexane-1,2-diamine ligands have been synthesized, and their molecular structures have been determined. The C 2 -symmetric diphosphine/diamine-based Ru complex acts as an excellent catalyst precursor in asymmetric transfer hydrogenation of acetophenone in a 0.1 M 2-propanol solution, leading to 2-phenylethanol in 97% ee and in 93% yield after 7 h at 45 °C. This transfer hydrogenation is characterized by low reversibility under these conditions.