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October 25, 2012Journal of the American Society of Nephrology

CKD and Sudden Cardiac Death

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Why the study?

Do pharmacologic and device-based therapies prevent sudden cardiac death in patients with chronic kidney disease?

Population

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD)

Design

Review

Authors

IWIsaac R. WhitmanElectrophysiologyHFHarold I. FeldmanRutgers, The State University of New JerseyRDRajat DeoElectrophysiology

Discussion

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Implication

Alerts clinicians to SCD risk in CKD without changing ICD practice; leaves open optimal preventive strategies for prospective trials.

Structured PICO

Do pharmacologic and device-based therapies prevent sudden cardiac death in patients with chronic kidney disease?

P
Population
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD)
I
Intervention
Pharmacologic (beta-blockers, statins, RAAS blockers) and device-based (implantable cardioverter-defibrillators) therapies
O
Outcome
Sudden cardiac death (SCD)hard clinical

This review highlights the independent association between CKD and sudden cardiac death, emphasizing the need for targeted risk stratification and prospective trials to evaluate the efficacy and safety of preventive therapies in this high-risk population.

Cite This Study

Whitman et al. (2012) studied this question.

synapsesocial.com/papers/6a7e0b5733dcb27c99cb67f6https://doi.org/10.1681/asn.2012010037

Topics

Cardiac device therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart Function in Patients with Chronic Glomerulonephritis and Mildly to Moderately Impaired Renal Function: An Echocardiographic Study1997 · 22 citations
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  3. 3QT Dispersion in Patients with End-Stage Renal Failure and during Hemodialysis1999 · 122 citations
  4. 4Out-of-Hospital Cardiac Arrest in the 1990s: A Population-Based Study in the Maastricht Area on Incidence, Characteristics and Survival1997 · 844 citations
  5. 5Endothelial Dysfunction and Mild Renal Insufficiency in Essential Hypertension2004 · 104 citations