This preclinical study identifies nectin-1 as the primary receptor mediating HSV-1 entry into sensory neurons.
Answers are grounded in this paper and cite their sources.
May guide HSV-1 entry inhibitor development; leaves open clinical translation from this animal model.
Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.
No takes yet. Share an insight, caveat, or question.
Richart et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: