Key result
Nectin1 mediates the direct cell-to-cell spread of wild-type HSV-1, but not syncytial strains, which can be blocked by monoclonal antibodies targeting nectin1.
Population
In vitro cell models including J cells expressing nectin1alpha or nectin1delta, parental receptor-negative J…
Comparison
Infection with wild-type HSV-1, syncytial… vs Receptor-negative cells or untreated infected…
Design
Preclinical
Authors
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Nectin1 blockade merits testing in HSV-1 animal models; leaves open translation to human infection or therapy.
The immunoglobulin-like receptors nectin1 and nectin2, which mediate HSV-1 entry, also mediate direct cell-to-cell spread of specific viral strains, highlighting a shared mechanism for entry and tissue spread.
Cocchi et al. (2000) studied Herpes Simplex Virus Type 1 (HSV-1) infection. MAb R1.302 (anti-nectin1 antibody) vs. Untreated or irrelevant monoclonal antibody was evaluated on Cell-to-cell spread of HSV-1 (plaque formation). Nectin1 mediates the direct cell-to-cell spread of wild-type HSV-1, but not syncytial strains, which can be blocked by monoclonal antibodies targeting nectin1.
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