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It has been shown by spectroscopy and by a Photosensitive Index method, involving measurements of interfacial tension, that Cu2+ and Ni2+ form 2:1 complexes with oxytetracycline and 1:1 complexes with demethylchlortetracycline. Fe2+, Zn2+, Mg2+ and Ca2+ form weaker 1:1 complexes with both drugs. The possibility is discussed of using metal ions to reduce photosensitization by tetracyclines in-vivo.
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Riaz et al. (1984) studied this question.
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