January 8, 2018Annals of Internal Medicine
Percutaneous Closure Versus Medical Treatment in Stroke Patients With Patent Foramen Ovale
Why the study?
Does percutaneous PFO closure reduce recurrent stroke or TIA in adults with PFO and cryptogenic stroke?
Population
2,531 adults with patent foramen ovale (PFO) and cryptogenic stroke (pooled from 4 RCTs)
Comparison
Percutaneous PFO closure using a commercially… vs Medical treatment alone
Design
Meta-analysis, Trials were not double-blind
Authors
Discussion
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Implication
Supports PFO closure consideration in cryptogenic stroke with PFO; confirms recurrent event reduction in randomized meta-analysis.
Structured PICO
Does percutaneous PFO closure reduce recurrent stroke or TIA in adults with PFO and cryptogenic stroke?
P
Population
2,531 adults with patent foramen ovale (PFO) and cryptogenic stroke (pooled from 4 RCTs)
I
Intervention
Percutaneous PFO closure using a commercially available device
C
Comparator
Medical treatment alone
O
Outcome
Composite of stroke or transient ischemic attack (TIA)composite
Percutaneous PFO closure reduces the risk of recurrent stroke or TIA in patients with cryptogenic stroke but increases the risk of new-onset atrial fibrillation or flutter.
Limitations
- Trials were not double-blind
- Inclusion criteria were heterogeneous
Cite This Study
Rosa et al. (2018) studied this question.