Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2025Discover Public HealthOpen Access

In the fully adjusted model, the risk of stroke in the highest WHtR quartile (≥ 0.654) was significantly increased compared to the lowest quartile (≤ 0.525) with an odds ratio of 1.22 (95% CI: 1.03–1.46, P = 0.025).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Few studies have investigated the relationship between waist-to-height ratio, an effective tool for assessing central obesity, and the risk of stroke among US adults.

Does a higher waist-to-height ratio increase the risk of stroke in American adults?

Population

43,278 individuals over 20 years of age from NHANES (1999–2023)

Comparison

Higher vs lower waist-to-height ratio quartiles

Design

Cross-sectional survey analysis

Authors

XPXiaohua Pan

Discussion

Loading...

Member takes

Overview

May support WHtR for stroke risk stratification in US adults; leaves open prospective validation versus established metrics.

Structured PICO

Does a higher waist-to-height ratio increase the risk of stroke in American adults?

P
Population
43,278 US adults over 20 years of age from the National Health and Nutrition Examination Survey (NHANES) 1999–2023, mean age 50.1, 50.8% female.
I
Intervention
Waist-to-height ratio (WHtR) as an exposure variable
C
Comparator
Lower waist-to-height ratio (lowest quartile Q1 ≤ 0.525)
O
Outcome
Self-reported diagnosis of strokehard clinical

Higher waist-to-height ratio is independently associated with an increased risk of stroke in US adults, suggesting it could be a useful anthropometric predictor for stroke risk stratification.

Limitations

  • Cross-sectional nature does not allow for causal inference
  • Residual confounding from unmeasured or unknown factors cannot be completely ruled out
  • Secondary analysis using a public database provides a lower level of evidence
  • Cannot analyze different stroke subtypes due to database limitations

Cite This Study

Xiaohua Pan (2025) studied this question.

synapsesocial.com/papers/6a7e12a9dbe98f45a79bd72fhttps://doi.org/10.1186/s12982-025-00882-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between the triglyceride glucose-waist-to-height ratio and stroke risk among middle-aged and elderly Chinese adults2025
  2. 2Predictive value of the waist-to-height ratio and HbA1c product for incident stroke: a stratified analysis by blood pressure status2026
  3. 3Measures of Abdominal Adiposity and the Risk of Stroke2011 · 88 citations
  4. 4Association of waist-to-height ratio with all-cause and obesity-related mortality in adults: a prospective cohort study2025
  5. 5Waist-to-height ratio and hypertension risk: a retrospective cohort analysis of the CHARLS2026 · 2 citations