MinK Residues Line a Potassium Channel Pore
Population
Preclinical model studying MinK potassium channel subunits
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Supports minK in K+ pore formation; extends channel models but leaves open in vivo and therapeutic relevance.
Structured PICO
P
Population
Preclinical model studying MinK potassium channel subunits
I
Intervention
Mutation of specific minK region to cysteine and exposure to methanethiosulfonate ethylsulfonate and tetraethylammonium
O
Outcome
Susceptibility to covalent blockade and reversible inhibitionsurrogate
This basic science study provides evidence that the minK protein is directly involved in forming the pore of a potassium-selective ion conduction pathway.
Cite This Study
Wang et al. (1996) studied this question.