Answers are grounded in this paper and cite their sources.
Enantioselective construction of pyrroloindolines via chiral phosphoric acid catalyzed cascade Michael addition-cyclization of tryptamines has been realized. With 5 mol % of chiral phosphoric acid, enantioenriched pyrroloindoline derivatives were obtained in good yields and enantioselectivity (up to 95% yield and 83% ee) from readily available tryptamines and enones.
No takes yet. Share an insight, caveat, or question.
Cai et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: