Thrombotic Thrombocytopenic Purpura

Letters and Corrections1 June 1982Thrombotic Thrombocytopenic PurpuraJ. HERMAN, M.D.J. HERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-791_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Rosove and colleagues (1) on the ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura underscores the difficulty in determining a therapeutic rationale for a condition of unknown cause, uncertain pathogenesis, and disputed definition (2, 3). The situation is further complicated by the widely differing degrees of severity manifested by this syndrome, which may follow a fulminant and rapidly fatal course, may be subacute and relatively mild (4), or even chronic and relapsing (5). Finally, reporting of treatment has not been standardized and it is often difficult, when perusing a case...References1. ROSOVE M, HO W, and GOLDFINGER D. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar2. ANSELL J, BEASER R, and PECHET L. Thrombotic thrombocytopenic purpura fails to respond to fresh plasma infusion. Ann Intern Med. 1979; 89:647-8. LinkGoogle Scholar3. LERNER R, RAPAPORT S, and MELTZER J. Thrombotic thrombocytopenic purpura. Serial clotting studies, relation to the generalized Schwartzman reaction and remission after adrenal steroid and dextran therapy. Ann Intern Med. 1967;66:1180-90. LinkGoogle Scholar4. KOHN D, HERMAN J, FLATAU E, DAHER O, LEV A, and DUBNOV B. Thrombotic thrombocytopenic purpura with a sub-acute course: remission after steroids and high-dose plasma exchange. Isr J Med Sci. 1981;17:283-5. MedlineGoogle Scholar5. CAHALANE S and HORN R. Thrombotic thrombocytopenic purpura of long duration. Am J Med. 1959;27:333-41. CrossrefMedlineGoogle Scholar1. ROSOVE M, HO W, and GOLDFINGER D. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. HERMAN, M.D.Affiliations: Family Medicine Clinic Beisan Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1982Volume 96, Issue 6_Part_1Page: 791-792KeywordsAspirinPathogenesisThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 June 1982 PDF downloadLoading ...