Key result
Enterovirus 71 infection linked to a nationwide epidemic of ~36,000 HFMD cases with low CNS involvement.
Why the study?
Enterovirus 71 was known to be associated mainly with central nervous system diseases rather than large-scale hand, foot and mouth disease epidemics outside Japan, prompting this summary of epidemiological data from the 1978 nationwide outbreak in Japan.
Observational (n=36,301)
Yes
Answers are grounded in this paper and cite their sources.
This epidemiological report documents the second large-scale nationwide outbreak of enterovirus 71-associated hand, foot and mouth disease in Japan in 1978, highlighting predominantly typical mucocutaneous symptoms and relatively low central nervous system involvement compared to European outbreaks.
An epidemic of hand, foot and mouth disease (HFMD) took place throughout Japan in 1978.A total of 36,301 cases were reported and clinical symptoms were mostly typical of HFMD.Most patients were under five years of age.This communication deals with the summarized results of epidemiological informa tion from various laboratories on the incidence of HFMD.Enterovirus 71 is known to be associated mainly with central nervous system (CNS) diseases in USA (Schmidt et al., 1974;Deibel et al., 1975), Australia
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TAGAYA et al. (1981) conducted an observational in Hand, foot and mouth disease (HFMD) (n=36,301). Enterovirus 71 infection was evaluated on Incidence and clinical manifestations of hand, foot and mouth disease and central nervous system involvement. Enterovirus 71 infection was associated with a nationwide epidemic of 36,301 reported cases of hand, foot and mouth disease in Japan in 1978, with predominantly typical symptoms and low CNS involvement.
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