Mechanistic chemical study demonstrates copper-catalyzed denitrogenative ring-opening to yield 2-acyl-quinazolines, indicating a thermodynamically driven Dimroth rearrangement.
a Cu-catalyzed denitrogenative ring-opening reaction under acidic conditions. The mechanism was investigated using additional DFT calculations, and the ring-opening and ring-closing (RORC) process of Dimroth rearrangement probably was driven by thermodynamic stability.
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Liu et al. (2025) studied this question.
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