Why the study?
What are the clinical, radiologic, and pathologic features that distinguish amiodarone pulmonary toxicity from non-toxic amiodarone use?
Population
20 patients taking amiodarone, including 15 with amiodarone pulmonary toxicity and 5 without evidence of…
Comparison
Amiodarone therapy with subsequent pulmonary… vs Amiodarone therapy without pulmonary toxicity
Design
Case-control
Authors
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Pathologic features alone cannot confirm amiodarone pulmonary toxicity; leaves open need for validated multimodal criteria in prospective studies.
What are the clinical, radiologic, and pathologic features that distinguish amiodarone pulmonary toxicity from non-toxic amiodarone use?
Pathologic findings such as foamy macrophages and lamellated inclusions are seen in both toxic and non-toxic amiodarone patients, meaning they cannot reliably diagnose amiodarone pulmonary toxicity on their own.
John I. Kennedy (1987) studied this question.
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