Why the study?
Does evoking the muscle chemoreflex alter blood flow and vascular conductance in nonischemic exercising skeletal muscle in dogs?
Does evoking the muscle chemoreflex alter blood flow and vascular conductance in nonischemic exercising skeletal muscle in dogs?
In a canine model, the muscle chemoreflex induces vasoconstriction in nonischemic exercising muscle, though the concurrent pressor response ultimately increases local blood flow.
Muscle chemoreflex effects on exercising perfusion are hypothesis-generating in canines; human relevance remains untested.
Previous studies have shown that the muscle chemoreflex causes an augmented blood pressure response to exercise and partially restores blood flow to ischemic muscle. The purpose of this study was to investigate the effects of the muscle chemoreflex on blood flow to nonischemic exercising skeletal muscle. During each experiment, dogs ran at 10 kph for 8-16 min and the muscle chemoreflex was evoked by reducing hindlimb blood flow at 4-min intervals (0-80%). Arterial blood pressure, hindlimb blood flow, forelimb blood flow, and forelimb vascular conductance were averaged over the last minute at each level of occlusion. Stimulation of the muscle chemoreflex caused increases in arterial blood pressure and forelimb blood flow and decreases in forelimb vascular conductance. The decrease in forelimb vascular conductance demonstrates that the muscle chemoreflex causes vasoconstriction in the nonischemic exercising forelimb. Despite the decrease in vascular conductance, the increased driving pressure caused by the pressor response was large enough to produce an increased forelimb blood flow.
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Mittelstadt et al. (1994) studied this question.
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