Key result
Muscle chemoreflex activation via reduced hindlimb blood flow significantly increased right atrial pressure from 5.1 to 7.4 mmHg (P < 0.05) in exercising dogs.
Why the study?
Does muscle chemoreflex activation increase right atrial pressure in exercising dogs?
Population
Conscious dogs exercising on a treadmill (n=4 for light exercise, n=5 for heavier exercise)
Comparison
Muscle chemoreflex activation via graded… vs Baseline conditions before reflex activation
Design
Preclinical
Authors
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Muscle chemoreflex may defend RAP during canine exercise; leaves open translation to human cardiovascular regulation.
Does muscle chemoreflex activation increase right atrial pressure in exercising dogs?
Absolute Event Rate: 7.4% vs 5.1%
p-value: p=<0.05
Muscle chemoreflex activation elicits peripheral vascular adjustments that successfully increase right atrial pressure, defending it against expected falls during increased cardiac output.
Sheriff et al. (1998) studied this question. Muscle chemoreflex activation via reduced hindlimb blood flow vs. Baseline (normal hindlimb blood flow) was evaluated on Right atrial pressure (RAP) (p=<0.05). Muscle chemoreflex activation via reduced hindlimb blood flow significantly increased right atrial pressure from 5.1 to 7.4 mmHg (P < 0.05) in exercising dogs.