Key result
Muscle metaboreflex activation at constant heart rate significantly increased stroke volume, sustaining cardiac output and systemic arterial pressure increases comparable to control experiments.
Population
Conscious, chronically instrumented dogs trained to run on a treadmill (3.2 km/h, 0% grade)
Comparison
Activation of the muscle metaboreflex via… vs Control experiments
Design
Preclinical
Authors
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Supports contractility role in metaboreflex pressor response; leaves open translation to human exercise physiology.
Muscle metaboreflex-induced increases in ventricular contractility act to sustain stroke volume despite decreases in ventricular filling time due to tachycardia, contributing importantly to the reflex increase in systemic arterial pressure.
O’Leary et al. (1998) studied this question. Muscle metaboreflex activation at constant heart rate vs. Muscle metaboreflex activation with uncontrolled heart rate (control) was evaluated on Changes in stroke volume, cardiac output, and systemic arterial pressure. Muscle metaboreflex activation at constant heart rate significantly increased stroke volume, sustaining cardiac output and systemic arterial pressure increases comparable to control experiments.
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